Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice
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چکیده
منابع مشابه
Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice
BACKGROUND In this study, we investigated the direct effect of C5a overexpression on atherosclerosis. METHODS AND RESULTS A recombinant adenovirus expressing mouse C5a (Ad-C5a) was constructed and injected intravenously into ApoE-/- mice. After 12 weeks of a high-fat diet, Ad-C5a injection produced more extensive lesions than control adenovirus, and its proathrosclerotic role was significantl...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.11180